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STRUCTURE ACTIVITY STUDIES ON SOMATOSTATIN
Author(s) -
SARANTAKIS D.,
McKINLEY W. A.,
JAUNAKAIS I.,
CLARK D.,
GRANT N. H.
Publication year - 1976
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1976.tb03835.x
Subject(s) - medicine , somatostatin , endocrinology , biology
SUMMARY Seven synthetic analogues of somatostatin helped clarify structural requirements for suppression of growth hormone secretion in rats. Size of the ring is not critical; deletions of serine‐13, lysine‐4 or asparagine‐5 result in peptides which retain an appreciable fraction of the activity. The analogue des‐Ala 1 , Gly 2 , Asn 5 ‐somatostatin lowers plasma growth hormone and insulin levels without affecting plasma glucagon levels significantly.