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TREATMENT OF HYPOPARATHYROIDISM WITH 1,25‐DIHYDROXYCHOLECALCIFEROL
Author(s) -
HILL L. F.,
DAVIES M.,
TAYLOR C. M.,
STANBURY S. W.
Publication year - 1976
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1976.tb03824.x
Subject(s) - hypoparathyroidism , hypercalcaemia , medicine , endocrinology , calcitriol , calcium , reabsorption , kidney
SUMMARY Five patients with hypoparath;yroidism (three post thyroidectomy and two idiopathic) were treated with synthetic 1,25‐dihydroxycholecalciferol (1,25‐(OH) 2 ‐D 3 ) for up to 6 months. In each case daily oral administration of 1 μg 1,25‐(OH) 2 D 3 either alone or with additional calcium, raised the serum calcium into the normal range. The serum pnhosphorus and the renal tubular reabsorption of phosphorus fell during treatment. None of these patients developed hypercalcaemia and no other complications of treatment have been recorded. 1,25‐(OH) 2 D 3 seems to represent a significant improvement over conventional methods for treating hypoparath;yroidism.