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TOTAL THYROIDAL CONTENT OF IODINE IN THYROTOXIC PATIENTS MEASURED BY IN VIVO NEUTRON ACTIVATION ANALYSIS
Author(s) -
ROBERTSON I.,
BODDY K.,
HOOPER M. J.,
STEVENSON R. D.,
McGHIE T.,
ALEXANDER W. D.,
WILSON G. M.
Publication year - 1976
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1976.tb02826.x
Subject(s) - iodine , in vivo , endocrinology , medicine , thyroid , chemistry , biology , microbiology and biotechnology , organic chemistry
This paper describes an in vivo method for measurign total thyroidal iodine stores by activation analysis, its evaluation and measurements in thyrotoxic patients. There was good correlation between measurements of solutions of iodine and post‐mortem thyroids by activation analysis and chemical analysis. Measurements in thyrotoxic patients showed low levels in untreted and treated (antithyroid drugs) patients and a marked increase in patients studied whilst in clinical remission. The practical importance of this method of measurement of thyroidal iodine stores is that it is a relaible in vivo measurement obtained at a single visit and should enable the definition of the relationship of thyroidal iodine stores to pathophysiology and prognosis.