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EFFECT OF DOPAMINE INFUSION ON PLASMA LEVELS OF GROWTH HORMONE IN NONMAL SUBJECTS AND IN AGROMEGALIC PATIENTS
Author(s) -
VERDE G.,
OPPIZZI G.,
COLUSSI G.,
CREMASCOLI G.,
BOTALLA L.,
MÜLLER E. E.,
SILVERSTRINI F.,
CHIODINI P. G.,
LIUZZI A.
Publication year - 1976
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1976.tb01971.x
Subject(s) - growth hormone , humanities , medicine , endocrinology , hormone , philosophy
In ten normal subjects and in twenty acromegalic patients plasma levels of growth hormone were studied after administration of L-dopa and a dopamine infusion. In the ten normal subjects L-dopa, but not dopamine, increased plasma levels of GH. In the acromegalic patients both L-dopa and dopamine were followed by an inhibition of GH release. Since dopamine does not cross the blood-brain barrier, these results, although not excluding a site of action at median eminence level, support the thesis that the inhibitory effect of dopaminergic stimulation on GH release in acromegaly possibly involves receptors present on GH-secreting cells.