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EFFECT OF OESTRADIOL ON GONADOTROPHIN RELEASE INDUCED BY LHRH IN MEN
Author(s) -
D'AGATA R.,
GULIZIA S.,
ANDÓ S.,
VITALE G.,
POLOSA P.
Publication year - 1976
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1976.tb01967.x
Subject(s) - medicine , endocrinology , gonadotropin , hormone , chemistry
SUMMARY In order to study the role of the oestradiol on the feed‐back mechanism, fourteen men were subjected to LHRH test before and after treatment with oestradiol. The oestrogen was administered i.m., 3 μg/kg/24 h and 150 μg/kg/24 h, in two groups of patients. Doses of 3 and 150 μg respectively produced a reduction of LH release of 74% and 60% below control. FSH response to LHRH was almost abolished by oestrogens. Our findings show that oestrogensin men decrease the pituitary response to LHRH.