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RESPONSE OF PLASMA TESTOSTERONE, URINARY 17‐OXOSTEROIDS, OESTROGENS, AND ANDROSTERONE PLUS AETIOCHOLANOLONE TO HUMAN CHORIONIC GONADOTROPHIN IN DEXAMETHASONE‐SUPPRESSED MEN
Author(s) -
METCALF M. G.,
COWLES R. J.
Publication year - 1976
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1976.tb01949.x
Subject(s) - androsterone , endocrinology , medicine , testosterone (patch) , urinary system , dexamethasone , etiocholanolone , urine , human chorionic gonadotropin , excretion , chemistry , hormone , steroid
SUMMARY The administration of human chorionic gonadotrophin (HCG) to dexamethasone‐suppressed men caused parallel changes in the concentration of plasma testosterone and in the urinary output of androsterone+aetiocholanolone, total 17‐oxosteroids and oestrogens. Discrepant results occurred in only four of the thirty‐seven men tested. With these exceptions, the response to HCG could be followed as well by measuring androsterone+aetiocholanolone, 17‐oxosteroid or oestrogen excretion rates as by following plasma testosterone levels. The most sensitive index of response was the rate of appearance of oestrogens in urine, and the next that of androsterone+aetiocholanolone.