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FETAL HYPOTHYROIDISM COMPLICATING MEDICAL TREATMENT OF THYROTOXICOSIS IN PREGNANCY
Author(s) -
IBBERTSON H. K.,
SEDDON R. J.,
CROXSON M. S.
Publication year - 1975
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1975.tb01563.x
Subject(s) - medicine , triiodothyronine , endocrinology , pregnancy , gestation , fetus , antithyroid agent , hormone , thyroid , graves' disease , genetics , biology
SUMMARY Two women with thyrotoxicosis were treated with antithyroid drugs during pregnancy. One women had inadvertently received a therapeutic dose of radioiodine at 21 weeks gestation and the other suffered from severe thyrotoxicosis with a serum LATS level of 1850%. In both patients, the serum triiodothyronine was maintained above 500 ng/dl by the concurrent oral administration of this hormone. Despite this precaution, cord serum thyrotrophin levels were markedly elevated and both infants showed clinical signs of hypothyroidism at birth. This experience indicates that triiodothyronine does not prevent fetal hypothyroidism when given to the mother in pharmacological amounts.