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FAILURE OF ADRENERGIC α AND β RECEPTOR BLOCKADE TO ELEVATE THE TSH AND PROLACTIN RESPONSE TO TRH IN HYPERTHYROIDISM
Author(s) -
EPSTEIN S.,
PIMSTONE B. L.,
VINIK A. I.,
McLAREN H.
Publication year - 1975
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1975.tb01560.x
Subject(s) - endocrinology , medicine , prolactin , blockade , receptor , adrenergic receptor , hormone
SUMMARY The effects of adrenergic α and β receptor blockade on the thyrotrophin and prolactin responses to TRH were studied in groups of hyperthyroid patients who received either oral propranolol and phenoxybenzamine or intravenous propranolol and rogitine. The flat TSH and prolactin responses to TRH in the untreated hyperthyroid patients were not altered by oral or intravenous adrenergic α and β receptor blockade suggesting that catecholamines do not play a major role in the feedback suppression of TSH and prolactin in hyperthyroidism.