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PLASMA GLUCAGON RESPONSE TO ARGININE INFUSION IN CHILDREN AND ADOLESCENTS WITH DIABETES MELLITUS
Author(s) -
JOSEFSBERG Z.,
LARON Z.,
DORON M.,
KERET R.,
BELINSKI YOAV,
WEISMANN I.
Publication year - 1975
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1975.tb01558.x
Subject(s) - medicine , glucagon , endocrinology , arginine , basal (medicine) , diabetes mellitus , decompensation , insulin , plasma glucose , chemistry , biochemistry , amino acid
SUMMARY Plasma glucagon response to an arginine infusion was studied in children and adolescents belonging to the following groups: (I) twenty‐two controls; (II) six subjects with delayed insulin peak during oral GTT; (III) ten diabetics on diet and/or oral therapy; (IV) six newly diagnosed uncompensated diabetics; and (V) eight diabetics on insulin therapy. The fasting glucagon concentrations and rise of glucagon in response to arginine in the patients of Groups II, III and V were similar to those of the controls (Group I). The basal levels and rise of glucagon in the newly diagnosed, uncompensated diabetic children (Group IV) was elevated compared to the other groups but the difference was statistically not significant. The results of this investigation favour the hypothesis that the hyperglucagonaemia in diabetes is a secondary effect to the metabolic derangement, bearing a direct relationship to the degree of homeostastic decompensation.