Premium
SPECIFIC CONTROL OF FOLLICLE STMULATING HORMONE IN THE MALE: POSTULATED SITE OF ACTION OF INHIBIN
Author(s) -
BRAMBLE F. J.,
HOUGHTON A. L.,
ECCLES SHEILA S.,
MURRAY M. A. F.,
JACOBS H. S.
Publication year - 1975
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1975.tb01552.x
Subject(s) - medicine , endocrinology , follicle stimulating hormone , luteinizing hormone , basal (medicine) , leydig cell , testosterone (patch) , oligospermia , hormone , gonadotropin , hypothalamic–pituitary–gonadal axis , spermatogenesis , biology , gonadotropin releasing hormone , hypothalamus , infertility , azoospermia , pregnancy , genetics , insulin
SUMMARY Serum luteinizing and follicale stimulating hormone concentrations were related to gonadal function, as reflected by sperm count and serum testosterone concentrations, in a group of men studied over 10 years after surgical correction of bilateral crytorchidism in childhood. The results indicated that while all degrees of gonadal function occurred in these patients, the main adverse effect of crytorchidism was on spermatogenesis. In some of the patients with oligospermia and normal Leydig cell function there was an isolated increease f basal serum FSH concentrations, suggesting a specific iompairment of the testicular production of ‘inhibin’. Gonadotrophin releasing hormone (LHRH) tests in thesse patients were conpared to those in patients with normal basal gonadotrophins and to those with elevated basal LH and FSH concentrations. A selective exaggeration of the FSH response to expgenous LHRH in the group of patients with a monotropic elecation of FSH conventration suggests that ‘inhibnin’ modulates the secretion of FSH by an action on the pituitary rather than by modifying endogenous LHRH production by the hypothalamus.