Premium
IODINE ORGANIFICATION DEFECT FOLLOWING TREATMENT OF THYROTOXICOSIS WITH ANTITHYROID DRUGS
Author(s) -
HORTON P. W.,
MILLAR W. T.,
McLARTY D. G.,
ALEXANDER W. D.
Publication year - 1975
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1975.tb01544.x
Subject(s) - organification , antithyroid agent , medicine , endocrinology , antithyroid drugs , carbimazole , propylthiouracil , iodine , graves' disease , thyroid , chemistry , organic chemistry
SUMMARY Two patients remained clinically euthyroid following treatment for thyrotoxicosis with antithyroid drugs in spite of persistently elevated thyroid radioiodine uptakes not suppressable by exogenous triiodothyronine. Perchlorate discharge tests showed a defect in the intrathyroidal organification of iodine. Circulating levels of thyroxine were normal. From our study of 105 patients treated for thyrotoxicosis with antithyroid drugs, apparent remission of thyrotoxicosis by this mechanism might occur in up to 2% of patients.