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SERUM TRIIODOTHYRONINE 7–15 YEARS AFTER FRACTIONATED LOW DOSE RADIOIODINE THERAPY OF THYROTOXICOSIS
Author(s) -
HERRMANN J.,
SCHAPS D.,
RUSCHE H. J.,
BERGER M.,
KRÜSKEMPER H. L.,
MÜHLEN A.,
HACKENBERG K.,
REINWEIN D.
Publication year - 1975
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1975.tb01528.x
Subject(s) - endocrinology , triiodothyronine , medicine , radioiodine therapy , thyroid , thyroid cancer
SUMMARY In 189 of 334 patients, who had been treated with fractionated doses of radio‐iodine for Graves' disease 7–15 years ago, the serum concentrations of triiodothyronine have been estimated in addition to the following parameters: Protein bound 127 iodine (PB 127 I), free thyroxine index, cholesterol‐ and TSH‐level in serum, tendon reflex time and clinical index according to Billewitz et al. (1969). In forty‐one of the 189 sera the free T4 (AFT4) and free T3 (AFT3) concentrations were measured as well. The following hormonal and clinical patterns were observed:1 Euthyroidism, with all parameters within the normal range in 148 patients (= 78.4%). 2 Hypothyroidism with low serum T3, PBI, AFT4, AFT3 and elevated TSH in six subjects (= 3.2%). 3 Persistent hyperthyroidism with increased thyroid hormone concentrations and low TSH in seven cases (= 3.7%). 4 In twenty‐eight clinically euthyroid patients (= 14.8%) TSH was elevated with normal PBI and AFT4. Twenty of these subjects had a low normal T3 and in nine the T3 was clearly in the hypothyroid range (40 ± 12 μg/dl). 5 The constellation of normal T3, low T4 and elevated TSH, which has been frequently found after radioiodine therapy, has been seen in only moderate form in ten cases.