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COMPARISON OF THE EFFECTS OF ETHINYL OESTRADIOL AND CONJUGATED EQUINE OESTROGENS IN OOPHORECTOMIZED WOMEN
Author(s) -
BOLTON C. H.,
ELLWOOD M.,
HARTOG M.,
MARTIN R.,
ROWE A. S.,
WENSLEY R. T.
Publication year - 1975
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1975.tb01521.x
Subject(s) - medicine , endocrinology , luteinizing hormone , estrone , hormone , estrogen , triglyceride , fibrinogen , follicle stimulating hormone , menopause , cholesterol
SUMMARY Seventeen oophorectomized women were treated for 3 month periods, in random sequence, with ethinyl oestradiol 20 and 50 μg daily and conjugated equine oestrogens (Premarin) 0.625 and 1.25mg daily. The serum cholesterol, clot lysis time, plasma fibrinogen, platelet adhesiveness and activated partial thromboplastin time remained unchanged throughout the different oestrogen regimes. There was a significant rise of serum triglyceride levels on both doses of ethinyl oestradiol but no significant change with Premarin. Serum luteinizing hormone levels were depressed most by ethinyl oestradiol 50 μg daily, although not down to the levels in premenopausal women.