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A COMPARISON OF EFFECTIVE THYROXINE RATIO, FREE THYROXINE INDEX AND FREE THYROXINE CONCENTRATION IN CORRECTING FOR THYROXINE‐BINDING ABNORMALITIES IN SERUM
Author(s) -
WELLBY M. L.,
O'HALLORAN M. W.,
MARSHALL JANET
Publication year - 1974
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1974.tb03297.x
Subject(s) - free thyroxine , euthyroid , endocrinology , medicine , thyroxine binding proteins , chemistry , thyroid function tests , thyroid function , thyroid
SUMMARY The effective thyroxine ratio (ETR), a single test of thyroid function which has a highly significant linear correlation with serum free thyroxine (T 4 ) concentration, was assessed for its effectiveness in distinguishing the euthyroid state in subjects with abnormalities of T 4 ‐binding proteins. In patients with low activity of T 4 ‐binding proteins, the diagnostic accuracy of the ETR (80±5%) is superior to that of the free T 4 index (62±5%) and free T 4 concentration (67%). In patients with elevated T 4 ‐binding proteins the diagnostic accuracy of ETR was even higher at 93±5% and again better than the free T 4 index (83%) and the free T 4 concentration (91%).