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3 H‐OESTRADIOL UPTAKE IN VIVO BY HUMAN UTERINE ENDOMETRIUM: EFFECT OF TAMOXIFEN (I.C.I. 46,474)
Author(s) -
LUNAN C. B.,
GREEN B.
Publication year - 1974
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1974.tb02818.x
Subject(s) - tamoxifen , endometrium , endocrinology , medicine , myometrium , in vivo , uterus , chemistry , cytosol , hysterectomy , in vitro , hormone , biology , cancer , biochemistry , pathology , microbiology and biotechnology , breast cancer , enzyme
3 H‐oestradiol was injected subcutaneously into patients 2 hr prior to hysterectomy. The amount of labelled hormone present at operation in fractions of uterine endometrium and in other tissues was measured. Patients pretreated with tamoxifen (I.C.I. 46,474) had lower levels of 3 H‐oestradiol in the nuclei of the uterine endometrium and of total labelled material in the myometrium than did untreated patients. In vitro , tamoxifen also inhibited the uptake of 3 H‐oestradiol into the nuclei of human uterine endometrium during tissue incubations and its binding to the cytosol receptors. Fibroids also showed active oestradiol uptake in vivo .