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A CASE OF TESTICULAR FEMINIZATION WITH XYY KARYOTYPE
Author(s) -
WESTARP CHRISTIAN VON,
KILLINGER DONALD W.,
VOLPÉ ROBERT
Publication year - 1974
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1974.tb02816.x
Subject(s) - endocrinology , medicine , feminization (sociology) , testicular feminization , karyotype , testosterone (patch) , human chorionic gonadotropin , biology , stimulation , disorders of sex development , andrology , hormone , genetics , chromosome , gene , androgen receptor , social science , prostate cancer , cancer , sociology
An unusual case of testicular feminization is reported, characterized by a 47 XYY karyotype in blood and gonads. Plasma testosterone varied between 509 and 557 ng/100 ml. Testosterone production was normal at 6.18 mg/day. There was very little response to human chorionic gonadotrophin stimulation. Gonadectomy revealed small testes, only one of which was shown to be metabolically active.