Premium
ECTOPIC HORMONE PRODUCTION BY NON‐ENDOCRINE TUMOURS
Author(s) -
REES LESLEY H.,
RATCLIFFE J. G.
Publication year - 1974
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1974.tb01801.x
Subject(s) - hormone , endocrine system , endocrinology , medicine , secretion , biology , bioinformatics
The recognition that certain clinical syndromes are due to secretion of hormones by ‘non endocrine’ tumours, has been among the major developments in endocrinology in the last decade and has forged a new link with oncology. The phenomenon has general clinical and biochemical implications. Clinicians now recognize that the accompanying metabolic derangements may be more malign than the neoplams itself, may significantly affect prognosis, and they use the measurement of plasma hormone levels and related substances for diagnosis and management. From the biochemical point of view, the study of ectopic hormone secretion provides new insight into the state of tissue differentiation. It serves as an excellent model for the broader field of inappropriate tumour products, since the structure of most hormones is known and because recent technical advances have improved methods for their purification and assay.