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THE ROLE OF TRIIODOTHYRONINE (T3) IN THE MAINTENANCE OF EUTHYROIDISM IN ENDEMIC GOITRE
Author(s) -
PHARAOH P. O. D.,
LAWTON N. F.,
ELLIS S. M.,
WILLIAMS E. S.,
EKINS R. P.
Publication year - 1973
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1973.tb00419.x
Subject(s) - triiodothyronine , endocrinology , medicine , endemic goitre , thyroid
SUMMARY Serum concentrations of triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) have been measured in subjects from an endemic goitrous area of New Guinea. An increase in TSH concentration and a decrease in T4 concentration was found in both goitrous and non‐goitrous subjects, both abnormalities being more frequent in the goitrous group. In the majority of subjects (93%) the T3 level fell within the normal range. Euthyroidism appears to be preserved in the iodine deficient state by the continued production of normal amounts of T3, the intrinsic metabolic activity of T4 being relatively unimportant.