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Plasma Unconjugated and conjugated 17‐hydroxycorticosteroids in different clinical disorders
Author(s) -
PAL S. B.
Publication year - 1973
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1973.tb00414.x
Subject(s) - hydroxycorticosteroids , medicine , endocrinology , conjugated system , dexamethasone , stimulation , chemistry , urine , organic chemistry , polymer
SUMMARY A procedure was developped for the estimation of plasma unconjugated and conjugated 17‐hydroxycorticosteroids as 17‐oxogenic steroids. The reliabiligy criteria of the method were assessed. In 100 normal individuals, aged between 15 and 65 years, the average concentrations of junconjugated 17‐hydrosycorticosteroids were 12 ug/100 ml (range 10‐32) and of conjugated 17‐hydroxycorticosterods were 12 ug/100 ml (range 10‐32) and of conjugated 17‐hydroxycorticosteroids 16 ug/100 ml (range 15‐52). When an adrenal stimulation test was performed, the concnetrations of these two groups of steroids showeed a twofold increase after the administration of ACTH and the concentrations decreased after an adrenal suppression test with dexamethasone. Patients with rheumatoid arthiritis not previously treated with steroids or ACTH, Cushing's syndrome, carcinoma, were studied. The results showed that the determination of plasma unconjugated and conjugated corticosteroids in these patients is clinically more meaningful than the estimation of plasma cortisol alone.