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PORCINE CALCITONIN AS A RENAL VASODILATOR IN MAN
Author(s) -
EDWARDS I. R.,
SMITH A. J.
Publication year - 1972
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1972.tb00403.x
Subject(s) - endocrinology , medicine , calcitonin , chemistry , bicarbonate , excretion , sodium , urinary system , vasodilation , renal physiology , urea , kidney , renal function , renal blood flow , potassium , biochemistry , organic chemistry
SUMMARY Porcine calcitonin in intravenous doses of 1, 5, 10 and 20 MRC units produced acute increases in urinary volume and sodium, potassium, chloride and bicarbonate excretion in four normal subjects. Infusion of 10 MRC units over a 30 min period in six normal men produced significant increases in urinary volume and sodium, calcium, magnesium, chloride and urea excretion. Urinary potassium, phosphate and bicarbonate were also increased but the increases were not significantly different from control values. These changes in urinary composition accompanied a significant increase in effective renal plasma flow (para‐amino hippurate clearance) and a smaller increase in inulin clearance. It is suggested that porcine calcitonin acts as a renal vasodilator in man and that changes in renal electrolyte excretion occur as a consequence. It is possible that renal vasodilation is effected by an active intermediary released by calcitonin rather than by the hormone itself.