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MEASUREMENT OF PROGESTERONE IN HUMAN PLASMA
Author(s) -
HORTH C. E.,
PALMER R. F.
Publication year - 1972
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1972.tb00391.x
Subject(s) - luteal phase , endocrinology , medicine , follicular phase , menstrual cycle , menstruation , plasma concentration , chemistry , biology , hormone
SUMMARY A rapid protein‐binding technique is described for routine plasma progesterone measurements. Chick plasma is the source of binding‐protein and 3 H‐progesterone is the radioligand. Accuracy is ensured by including a recovery determination with each specimen. In fifteen normal female volunteers, low plasma progesterone values‐0.65 ng/ml ± 0.82 (SD)‐were recorded during the follicular phase of the menstrual cycles, rising 10‐14 days before menstruation to peak levels of 9–17 ng/ml during the luteal phase and then falling abruptly towards the end of the cycle.