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HUMAN NEUROPHYSINE BLOOD LEVELS UNDER NORMAL, EXPERIMENTAL AND PATHOLOGICAL CONDITIONS
Author(s) -
LEGROS J. J.,
FRANCHIMONT P.
Publication year - 1972
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1972.tb00382.x
Subject(s) - endocrinology , medicine , endocrine system , adrenal insufficiency , pathological , placental insufficiency , pregnancy , ingestion , anterior pituitary , hormone , fetus , biology , placenta , genetics
SUMMARY The first results of serum neurphysine determinations by radioimmunoassay in normal man and in several pathological states are reported. Under baseline conditions neurophysine levels are higher in women than in men. In women, moreover, they are elevated during pregnancy and decline rapidly postpartum. During labour and suckling there is no significant change in maternal neurophysine. Neonates, and particularly premature infants, have higher serum neurophysine concentrations than adults. Under certain physiological conditions (water load, dehydration) there is a concordance between serum neurophysine and antidiuresis, whereas these two factors are discordant in states marked by endocrine alterations (anterior pituitary insufficiency, adrenal insufficiency, oestrogen ingestion). A dissociation between neurophysine levels and antidiuresis is also observed during nicotine stimulation by cigarette inhalation. The significance of this dissociation is discussed. Renal insufficiency whether or not treated by dialysis is accompanied by constatly elevated neurophysine levels, while obesity is sometimes although not always associated with a marked increase in neuropysine. A rise in serum neurophysine is seen only rarely in anterior pituitary insufficiency.