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KINETIC STUDIES OF CORTISOL AND SYNTHETIC CORTICOSTEROIDS IN MAN
Author(s) -
Fell P. J.
Publication year - 1972
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1972.tb00378.x
Subject(s) - betamethasone , endocrinology , medicine , prednisolone , hydrocortisone , corticosteroid , endogeny , transcortin , globulin
SUMMARY Following the rapid intravenous injection of corticosteroids (cortisol, prednisolone, betamethasone and betamethasone‐17‐valerate), the blood levels of each were estimated and the results analysed in a two‐compartment open model. The kinetic analysis revealed differences in distribution and elimination which could have important therapeuticimplications. A theory is presented for the marked differences seen, and the therapeutic importance of these is discussed.