Open AccessAbnormal expansion of naïve B lymphocytes after unrelated cord blood transplantation – a case report
Author(s) -
SHONO Y.,
TOUBAI T.,
OTA S.,
IBATA M.,
MASHIKO S.,
HIRATE D.,
MIURA Y.,
UMEHARA S.,
TOYOSHIMA N.,
TANAKA J.,
ASAKA M.,
IMAMURA M.
Publication year - 2006
Publication title -
clinical & laboratory haematology
Language(s) - English
Resource type - Journals
eISSN - 1365-2257
pISSN - 0141-9854
DOI - 10.1111/j.1365-2257.2006.00809.x
Subject(s) - cd19 , cord blood , b cell , transplantation , medicine , immunoglobulin d , immunology , bone marrow , lymphocyte , peripheral blood , antibody
Summary A 33‐year‐old woman underwent unrelated cord blood transplantation (U‐CBT) for myelodysplastic syndrome (MDS)‐related secondary AML. She showed impressive increases in the number of CD19 + B cells in bone marrow and CD19 + 27 − IgD + B cells in peripheral blood from about 1 month to 3 months after U‐CBT. The serum level of IL‐6 temporarily increased after transplantation, and this increase seemed to be correlated with the expansion of CD19 + B cells. Although, compared with BMT, little is known about the kinetics of hematological and immunological reconstitution in U‐CBT, there was initial B‐cell recovery after CBT as some described. This B cell recovery may be associated with a high number of B‐cell precursors present in cord blood (CB). The phenomenon of naïve B lymphocyte expansion that we found might be associated with a high number of B‐cell precursors present in CB.