Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality? | Zendy

Simoni Y. | Zendy; Diana J. | Zendy; Ghazarian L. | Zendy; Beaudoin L. | Zendy; Lehuen A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Therapeutic manipulation of natural killer (NK) T cells in autoimmunity: are we close to reality?

Author(s) -

Simoni Y.,

Diana J.,

Ghazarian L.,

Beaudoin L.,

Lehuen A.

Publication year - 2013

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/j.1365-2249.2012.04625.x

Subject(s) - immunology , autoimmunity , major histocompatibility complex , natural killer t cell , population , biology , primary biliary cirrhosis , innate lymphoid cell , t cell , innate immune system , immune system , medicine , environmental health

Summary T cells reactive to lipids and restricted by major histocompatibility complex (MHC) class I‐like molecules represent more than 15% of all lymphocytes in human blood. This heterogeneous population of innate cells includes the invariant natural killer T cells (iNK T), type II NK T cells, CD1a,b,c‐restricted T cells and mucosal‐associated invariant T (MAIT) cells. These populations are implicated in cancer, infection and autoimmunity. In this review, we focus on the role of these cells in autoimmunity. We summarize data obtained in humans and preclinical models of autoimmune diseases such as primary biliary cirrhosis, type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, psoriasis and atherosclerosis. We also discuss the promise of NK T cell manipulations: restoration of function, specific activation, depletion and the relevance of these treatments to human autoimmune diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research