Antibody fragments as tools in crystallography | Zendy

Griffin L. | Zendy; Lawson A. | Zendy

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Antibody fragments as tools in crystallography

Author(s) -

Griffin L.,

Lawson A.

Publication year - 2011

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/j.1365-2249.2011.04427.x

Subject(s) - antibody , drug discovery , computational biology , immunology , biology , medicine , bioinformatics

Summary While antibody‐based therapeutics have become firmly established as front‐line drugs, the use of antibodies as research tools in small molecule drug discovery is still in its infancy. In this review we focus on the use of antibody fragments as crystallization chaperones to aid the structural determination of otherwise ‘uncrystallizable’ or ‘undruggable’ target proteins. We also highlight a potential application for this technology, in which antibody‐mediated structures may be used to inform the design of new chemical entities.

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