Pamidronate infusion in patients with systemic sclerosis results in changes in blood mononuclear cell cytokine profiles | Zendy

Carbone L. D. | Zendy; Warrington K. J. | Zendy; Barrow K. D. | Zendy; Pugazhenthi M. | Zendy; Watsky M. A. | Zendy; Somes G. | Zendy; Ingels J. | Zendy; Postlethwaite A. E. | Zendy

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Pamidronate infusion in patients with systemic sclerosis results in changes in blood mononuclear cell cytokine profiles

Author(s) -

Carbone L. D.,

Warrington K. J.,

Barrow K. D.,

Pugazhenthi M.,

Watsky M. A.,

Somes G.,

Ingels J.,

Postlethwaite A. E.

Publication year - 2006

Publication title -

clinical & experimental immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.329

H-Index - 135

eISSN - 1365-2249

pISSN - 0009-9104

DOI - 10.1111/j.1365-2249.2006.03216.x

Subject(s) - peripheral blood mononuclear cell , cytokine , medicine , immunology , tumor necrosis factor alpha , interferon gamma , lymphocyte , in vitro , biology , biochemistry

Summary A single infusion of pamidronate was given to patients with systemic sclerosis (scleroderma, SSc) to assess effects on cytokine production by peripheral blood mononuclear cells (PBMC) and lymphocyte subsets. Eighteen patients with SSc received a single intravenous dose of 60 mg of pamidronate and were followed for 6 months. Assessment of cytokine production [interferon (IFN)‐γ, interleukin (IL)‐10, transforming growth factor (TGF)‐β1, tumour necrosis factor (TNF)‐α and IL‐4] by PBMC and lymphocyte subsets by flow cytometry was carried out before and after the pamidronate infusion. Unstimulated PBMC produced increased amounts of IFN‐γ and TNF‐α and reduced levels of TGF‐β1 for up to 24 weeks after the infusion. γδ T cells from patients with SSc were activated in vitro and produced increased IFN‐γ. The effects of pamidronate on modulation of cytokine profiles in patients with SSc may merit future study.

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