Open AccessHigh levels of the soluble form of CD30 molecule in rheumatoid arthritis (RA) are expression of CD30 + T cell involvement in the inflamed joints
Author(s) -
GERLI R.,
MUSCAT C.,
BISTONI O.,
FALINI B.,
TOMASSINI C.,
AGEA E.,
TOGNELLlNI R.,
BIAGINI P.,
BERTOTTO A.
Publication year - 1995
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1995.tb03851.x
Subject(s) - synovial fluid , immunology , cd30 , immune system , lymphokine , rheumatoid arthritis , cd8 , cd3 , synovial membrane , t cell , cytokine , medicine , synovitis , pathology , immunohistochemistry , osteoarthritis , alternative medicine
SUMMARY The CD30 is a surface molecule expressed by Th2‐type lymphokine‐producitig T cells upon activation. CD30‐expressing activated T cells release a soluble form of the molecule, which can be detectable both in vitro and in vivo . In the present study, high levels of soluble CD30 were found in peripheral blood and synovial fluid from patients with RA. However, CD30 + CD3 + cells, either CD4 + or CD8 + , were significantly present in synovial fluid, but not in peripheral blood, of RA patients. Serum values of soluble CD30 were higher in active than inactive RA patients and directly correlated with rheumatoid factor serum titres. These data strongly support an involvement of CD30+ T cells in the immune processes of rheumatoid synovitis, and may suggest a relationship between Th2‐type cytokine‐secreting T cells and the pathological response in RA.