Open AccessAge‐related changes in surface antigens on peripheral lymphocytes of healthy children
Author(s) -
OSUGI Y.,
HARA J.,
KURAHASHI H.,
SAKATA N.,
INOUE M.,
YUMURAYAGI K.,
KAWAHA K.,
OKADA S.,
TAWA A.
Publication year - 1995
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1995.tb03735.x
Subject(s) - immunology , peripheral , antigen , biology , medicine
SUMMARY The age‐related changes in proportion of various subsets within lymphocytes were investigated in cord blood and peripheral blood from healthy children and adults. The percentages of T and B cells did not show age‐related changes, whereas natural killer (NK) cells increased significantly with age. Within lymphocytes or the CD3 + T cell population the proportion of CD45RA bright+ lymphocytes decreased and that of CD45RO + cells increased, while that of CD45RA dim+ cells showed no age‐related change. Within lymphocytes, the percentage of CD45RA bright+ CD4 + cells decreased, together with a decline of that of CD4 + cells. The proportions of CD45RA bright+ CD8 + cells and S6F1 bright+ CD8 + cells increased with age, and the age‐dependent increase of the proportion of CD8 + cells seems to be mainly attributable to the increases in these subsets. The CD45RA dim+ CD4 + and CD45RA dim+ CD8 + cells co‐expressing CD45RO at a low level nevertheless showed no age‐related changes. In γδ T cells, both δTCS1 + and δTCS1 ‐ T cells increased with age, but the δTCS1 ‐ γδ T cells increased more than the δCS1 + subset. Among lymphocytes, the percentages of CD20 + , CD21 + and CD22 + cells remained similar, with no age‐related changes, but the proportion of CD5 + cells within lymphocytes or B cells decreased. The proportions of CD16 + NK cells among lymphocytes increased with age, and this change was attributable to the increase of CD56 + cells.