Open AccessTwo phenotypically distinct B lymphocytes (IgM high IgD low and IgM low IgD high ) in chronic gastric ulcer in the rat
Author(s) -
OHMIYA N.,
ITO M.,
OHBAYASHI M.,
ARISAWA T.,
GOTO H.,
TSUKAMOTO Y.,
HAYAKAWA T.,
ASAI J.
Publication year - 1995
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1995.tb03617.x
Subject(s) - granulation tissue , cd5 , spleen , phenotype , pathology , marginal zone , stomach , medicine , lesion , immunology , biology , b cell , antigen , wound healing , antibody , biochemistry , gene
SUMMARY We determined the kinetics and phenotypes of infiltrating B cells in gastric ulcer in the rat induced by gastric injection of acetic acid (day 0). Few B cells were found in the lesion in the early stages of ulceration. On day 40, two kinds of B cells with phenotypes of IgM high IgD low OX33 (CD45) + OX19 (CD5) ‐ and IgM low IgD high OX33 (CD45) + OX19(CD5) ‐ were scattered in the granulation tissue of open ulcers, but not in the healed scar tissue. On day 180, those two kinds of B cells formed primary follicles in the granulation tissue of open ulcers, but were absent from the healed scar tissue. The IgM high IgD low OX33 (CD45) + OX19 (CD5) ‐ B cell was considered to be identical to the marginal zone B cell of rat spleen. This phenotype of B cell might be associated with inflammatory process in chronic gastric ulcer.