Open AccessEnhanced production of transforming growth factor‐beta (TGF‐β) during autologous mixed lymphocyte reaction of systemic sclerosis patients
Author(s) -
OTA H.,
KUMAGAI S.,
MORINOBU A.,
YANAGIDA H.,
NAKAO K.
Publication year - 1995
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1995.tb03609.x
Subject(s) - mixed lymphocyte reaction , transforming growth factor beta , immunology , fibrosis , scleroderma (fungus) , medicine , multiple sclerosis , lymphocyte , beta (programming language) , transforming growth factor , tgf beta signaling pathway , peripheral blood mononuclear cell , pathology , immune system , in vitro , biology , t cell , biochemistry , inoculation , computer science , programming language
SUMMARY Systemic sclerosis (SSc) is characterized by systemic fibrosis and microvascular lesions. As TGF‐β is suggested to be related to skin fibrosis, we examined the production of TGF‐β from peripheral mononuclear cells (MNC) of SSc patients. Since anti‐TGF‐β neutralizing antibody improved the defective proliferative response in autologous mixed lymphocyte reaction (AMLR) of SSc patients, TGF‐β was thought to participate in the decreased AMLR of SSc patients. Greater amounts of TGF‐β in the active as well as in the latent forms were produced during AMLR of SSc patients than that of normal subjects. It was suggested that TGF‐β excessively produced from the MNC of SSc patients might play a major role in the fibrosis of the patients during AMLR‐like in vivo responses.