Open AccessIL‐8 release from cultured peripheral blood monocytes of patients with glomerulonephritis
Author(s) -
MATSUMOTO K.
Publication year - 1995
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1995.tb03479.x
Subject(s) - glomerulonephritis , immunology , pathogenesis , nephropathy , proinflammatory cytokine , medicine , cytokine , chemotaxis , lipopolysaccharide , monocyte , peripheral blood , membranous nephropathy , inflammation , endocrinology , kidney , receptor , diabetes mellitus
SUMMARY IL‐8 is a chemotactic cytokine with proinflammatory and growth‐promoting activities. The release of IL‐8 was measured in supernatants of cultured peripheral blood monocytes (PBM) that were obtained from patients with glomerulonephritis (GN) and healthy controls. Spontaneous and lipopoly‐saccharide (LPS)‐induced IL‐8 release was significantly higher in PBM isolated from patients with IgA nephropathy (IgAN) and membranous nephropathy (MN) compared with normal controls. These results raise the question of whether IL‐8 contributes to the ongoing pathogenesis of GN, We cannot relate IL‐8 release to clinical and laboratory parameters in IgAN and MN patients. Thus, disease progression in vivo may not be accompanied by increased or sustained IL‐8 release.