Open AccessH‐2 b restriction of the immune response to the pl26 Plasmodium falciparum antigen
Author(s) -
BANIC D. M.,
DELPLACE P.,
MAZINGUE C.,
CAMUS D.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb07021.x
Subject(s) - congenic , antigen , biology , immune system , antibody , spleen , t lymphocyte , immunology , microbiology and biotechnology , virology , biochemistry , gene
SUMMARY Inbred BALB/c (H‐2 d ), CBA (H‐2 k ) and C57Bl/6 (H‐2%) mice immunized with Plasmodium falciparum schizonls or culture supernatcs develop antibodies of different anligcnic specificities. It has been observed that C57B1/6 mice were unable to produce deteelable antibodies against the pl26 antigen (native molecule and p73 or p50 processed fragments) compared with other inbred miee. Similar results were obtained using BALBeongenlc mice with a lack of p126 antibody response in H‐2 b mice, while H‐2 d and H‐2 k mice produced antibodies against the pl26. Lymphoeyte proliferation assays performed by incubation of spleen cells with immunopurified pl26 were positive for immunized BALB/c (H‐2 d ) and congenic H‐2 d or H‐2 k mice. On the other hand, no lymphocyte stimulation was observed with either C57B1/6 (H‐2 b ) or congenic H‐2 b miee. These results suggest an MHC restriction ofthe immune response against the entire pi 26 (found in schizonts) and its p73 and p50 naturally processed fragments (found in culture supernates).