Open AccessHigh levels of anti‐phospholipid antibodies in uncomplicated and severe Plasmodium falciparum and in P. vivax malaria
Author(s) -
FACER C. A.,
AGIOSTRATIDOU G.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb06528.x
Subject(s) - antibody , plasmodium falciparum , malaria , plasmodium vivax , immunology , cerebral malaria , immune system , phosphatidylserine , biology , immunoglobulin g , phospholipid , virology , biochemistry , membrane
SUMMARY The majority (75%) of adult patients with uncomplicated Plasmodium falciparum and P. vivax malaria are positive for anti‐phospholipid antibodies (aPLA) as demonstrated by ELISA using a panel of anionic and cationic phospholipids. The highest IgG and IgM binding was to the anionic phospholipids, phosphatidylserine (PS). phosphatidic acid (PA) and cardiolipin (CL), but excluding phosphalidylinositol (PI) to which only low antibody levels were found. Comparison of the mean IgG and IgM aPLA showed a trend for anti‐PA > CL> PS>PC> PE> PI, Anti‐PI levels were compared in two groups of African children, one group with non‐severe and the other with severe (cerebral) falciparum malaria. Children with cerebral disease had significantly lower IgM anti‐PI. The results are discussed with the view that serum‐derived aPLA may have a role in “anti‐disease” immune responses. Their possible role in the opsonization and phagocytosis of parasitized erythrocytes and in thrombocytopenia is also considered.