Open AccessProcessing and presentation of tetanus toxin by antigen‐presenting cells from patients with chronic granulomatous disease (CGD) to human specific T cell clones are not impaired
Author(s) -
BARBEY C.,
TIERCY J. M.,
FAIRWEATHER N.,
NIEMANN H.,
SEGER R.,
CORRADIN G.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb06515.x
Subject(s) - epitope , chronic granulomatous disease , immunology , antigen , tetanus , virology , biology , antigen presentation , t cell , antigen processing , medicine , vaccination , immune system
SUMMARY The capacity of peripheral blood lymphocytes (PBL) or Epstein‐Barr virus (EBV)‐transformed B cell lines from CGD patients to process and present tetanus toxin (tt)‐specific epitopes was assessed using various tt preparations and human tt‐specific T cell clones. PBL from all of the donors were able to process and present either native tt and/or denatured tt to human T cell clones specific for various tt epitopes. Furthermore, no difference was found in the antigen requirement when normal or CGD EBV‐B cell lines were used as antigen‐presenting cells (APC). These results suggest that the deficiency in oxygen metabolism in CGD cells does not affect tt processing and presentation.