Open AccessThe significance of the pre‐challenge immune status of mice for development of retrovirus‐induced immunodeficiency syndrome (MAIDS)
Author(s) -
PAVLOVITCH J. H.,
RIZKRABIN M.,
PICARD F.,
MARUSSIG M.,
HALBREICH A.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb06231.x
Subject(s) - immunology , immune system , virology , virus , immunodeficiency syndrome , immunodeficiency , viral disease , immunopathology , retrovirus , vaccination , immunity , biology , antigen , medicine
SUMMARY The effects of vaccination with RNA‐free viral pseudoparticles, preinfection with non‐pathogenic ecotropic virus, and induction of tolerance to viral proteins in newborns on the outcome of murine immunodeficiency syndrome (MAIDS) were studied. The parameters used to follow disease progression were: lymphopenia, circulating B and T 8 cells, serum IgG and IgM levels, lymphoproliferation and skin graft rejection, [minimization with RNA‐free viral pseudoparticles had no effect on any of these parameters. Preinfection of adults with ecotropic virus and the induction of tolerance in newborns to virus antigens both attenuated the early symptoms of viral infection and delayed the onset of immunodeficiency and lympho‐proliferation in some mice, but did not significantly alter the number of deaths due to MAIDS. Failure of immune‐based therapy to produce successful protection against MAIDS suggests that immune destruction caused by the persistent virus rather than hyper immune activity is the main pathogenic factor in this disease.