Open AccessMHC class I, MHC class II and intercellular adhesion molecule‐1 (ICAM‐1) expression in inflammatory myopathies
Author(s) -
BARTOCCIONI E.,
GALLUCCI S.,
SCUDERI F.,
RICCI E.,
SERVIDEI S.,
BROCCOLINI A.,
TONALI P.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb06032.x
Subject(s) - polymyositis , major histocompatibility complex , mhc class ii , antigen , immunology , mhc class i , mononuclear cell infiltration , peripheral blood mononuclear cell , intercellular adhesion molecule 1 , dermatomyositis , biology , inclusion body myositis , infiltration (hvac) , cell adhesion molecule , inflammation , microbiology and biotechnology , pathology , chemistry , medicine , in vitro , biochemistry , materials science , composite material
SUMMARY We investigated the relationship between the MHC‐I, MHC‐II and intercellular adhesion molecule‐1 (ICAM‐1) expression on myofibres and the presence of inflammatory cells in muscle specimens of 18 patients with inflammatory myopathies (nine polymyositis, seven dermatomyositis, two inclusion body myositis). We observed MHC‐I expression in muscle fibres, infiltrating mononuclear cells and endothelial cells in every specimen. In seven patients, some muscle fibres were MHC‐II‐positive for the DR antigen, while the DP and DQ antigens were absent. ICAM‐1 expression, detected in seven patients, was found in clusters of myofibres, associated with a marked MHC‐1 positivity and a widespread mononuclear infiltration. Most of the ICAM‐1‐positive fibres were regenerating fibres. Furthermore, some fibres expressed both ICAM‐I and DR antigens near infiltrating cells. This finding could support the hypothesis that myofibres may themselves be the site of autosensitization.