Open AccessSoluble intercellular adhesion molecule‐1 (ICAM‐1) in sera and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
Author(s) -
SHIJUBO N.,
IMAI K.,
SHIGEHARA K.,
HONDA Y.,
KOBA H.,
TSUJISAKI M.,
HINODA Y.,
YACHI A.,
OHMICHI M.,
HIRAGA Y.,
ABE S.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb06030.x
Subject(s) - bronchoalveolar lavage , idiopathic pulmonary fibrosis , medicine , sarcoidosis , icam 1 , lung , pulmonary fibrosis , pathology , immunology , intercellular adhesion molecule 1 , fibrosis , lymphocyte , respiratory disease , inflammation , cell adhesion molecule
SUMMARY ICAM‐1 plays an important role in inflammatory diseases. To assess level of soluble ICAM‐1 in the circulation and inflamed lesions, we measured levels of soluble ICAM‐1 in the circulation and bronchial veolar lavage fluid (BALF) of patients with idiopathic pulmonary fibrosis (IPF) and with pulmonary sarcoidosis (PS) and of healthy volunteers (HV), and we also analysed ICAM‐I expression of BALF cells in some patients and HV. IPF patients had significantly higher levels of circulating ICAM‐1 than HV, while PS patients did not. By contrast, significantly increased levels of BALF soluble ICAM‐1 were found in PS patients compared with those of HV, but not in IPF patients. There were no significant differences in the proportions of ICAM‐1 + BALF lymphocytes in IPF patients, PS patients and HV. whereas significantly increased proportions of ICAM‐1 pulmonary alveolar macrophages were found in PS patients compared with those of HV, but not in IPF patients. There was a significant positive correlation of BALF soluble ICAM‐1 levels to BALF lymphocyte proportions in PS patients. Although the source of BALF soluble ICAM‐1 is unclear. BALF soluble ICAM‐1 appears to reflect the grade of local activity of sarcoidosis. An interesting discrepancy between soluble ICAM‐1 levels in the circulation and BALF was found in IPF patients, and this might be an important clue to an understanding of this disorder.