Open AccessNeonatal capsaicin pretreatment suppresses intramedullary inflammation in adjuvant‐induced spondylitis
Author(s) -
IMAI S.,
HUKUDA S.,
MAEDA T.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb06023.x
Subject(s) - capsaicin , inflammation , medicine , adjuvant , immunology , spondylitis , ankylosing spondylitis , receptor
SUMMARY In order lo investigate the proposed involvement of neuropeptides in musculoskeletal inflammation we pretreated rats, in an adjuvant spondylitis model, with capsaicin, a neurotoxin. Immunohistochemistry showed that administration of capsaicin to newborn rats depicted irreversibly the neuropeptide substance P. Elimination of capsaicin‐sensitive fibres by the neonatal injection of capsaicin did not suppress the peridiscitis of rats in which adjuvant spondylitis was induced at 7 weeks of age. However, elimination of capsaicin‐sensitive fibres did suppress the inflammation usually seen in the bone marrow. We speculate that this intramedullary inflammation is normally induced or sustained by capsaicin‐sensitive fibres.