Open AccessIgG glycosylation in autoimmune‐prone strains of mice
Author(s) -
BODMAN K. B.,
HUTCHINGS P. R.,
JEDDI P. A.,
DELVES P. J.,
ROOK G. A. W.,
SUMAR N.,
ROITT M.,
LYDYARD P. M.
Publication year - 1994
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1994.tb06022.x
Subject(s) - arthritis , rheumatoid arthritis , immunology , immunization , medicine , adjuvant , antigen , biology
SUMMARY The relationship between increased levels of IgG oligosaccharide chains lacking galactose (GO) and the development of rheumatoid arthritis is unclear. In order to further our understanding of the observed correlation between raised serum GO and arthritis, we have studied GO levels in arthritis prone and non‐susceptible (i.e., non‐arthritis‐prone) mice and the effects on GO of mycobacterial antigens, which have been postulated to play a role in the early events leading to the development of arthritis. We have shown that different age‐matched mouse strains have characteristic “resting” levels of GO which (in six out of seven strains of mice) increase with age. We have also shown that these increases can be enhanced by immunization of arthritis‐prone strains of mice with an adjuvant containing mycobacteria (Freund's complete adjuvant (FCA)), suggesting that deflects in the ability to regulate these GO changes may be related to susceptibility to arthritis.