Open AccessSoluble tumour necrosis factor receptors (sTNF‐R) and HIV infection: correlation to CD8 + lymphocytes
Author(s) -
KALINKOVICH A.,
LIVSHITS G.,
ENGELMANN H.,
HARPAZ N.,
BURSTEIN R.,
KAMINSKY M,
WALLACHt D.,
BENTWICH Z.
Publication year - 1993
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1993.tb08184.x
Subject(s) - asymptomatic , immunology , cd8 , lymphocyte , medicine , antibody , aids related complex , immunopathology , t lymphocyte , arc (geometry) , biology , viral disease , human immunodeficiency virus (hiv) , immune system , geometry , mathematics
SUMMARY The objective or this study was to determine sTNF‐R, type I (p55) and type II (p75) in sera of HIV‐infected male homosexuals and correlate them to T lymphocyte subpopulations and course of HIV infection. Serum samples were obtained from 39 HIV‐1 + asymptomatic male homosexuals, 10 symptomatic (ARC and AIDS) male homosexuals and 44 HIV non‐homosexual healthy controls. sTNF‐R levels were determined by ELISA with specific MoAbs and polyclonal antibodies to the sTNF‐R proteins. sTNF‐RI and II levels were significantly elevated in 72% and 74%, respectively of HIV + asymptomatic male homosexuals and in all of the symptomatic male homosexuals. In sequential studies a highly significant positive correlation was found between sTNF‐RI and sTNF‐ RII ( r =0.8, P <0.00))and between both sTNF‐R and CD8 + lymphocyte counts ( r = 0.6 and 0.92. respectively, P <0.01–0.001) during the asymptomatic stage of the infection. All these correlations were lost, however, during the symptomatic phase of the disease. These results suggest that: (i) HIV infection is associated with elevation of sTNF‐R serum levels; (ii) sTNF‐R levels arc strongly correlated to CDS + lymphocytes during the asymptomatic stage of HIV infection.