Open AccessThe anti‐arthritic and immunosuppressive effects of cyclosporin A on collagen‐induced arthritis in the rhesus monkey
Author(s) -
BAKKER N. P. M.,
BESOUW N.,
GROENESTEIN R.,
JONKER M.,
'tHART L. A.
Publication year - 1993
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1993.tb08179.x
Subject(s) - arthritis , medicine , immunology , immunization , type ii collagen , rheumatoid arthritis , antibody , toxicity , dosing
SUMMARY The influence of cyclosporin A (CsA) on type II collagen‐induced arthritis (CIA) in the rhesus monkey has been investigated. CsA was administered subcutaneously in a dose of 25 mg/kg per day during 9 18 days and additionally 12–5 mg/kg per day for 7 days. At this dosing regime no significant alterations of hacmalologic parameters were found, indicating that the toxicity of CsA was negligible. Administration of CsA after onset of arthritis had no beneficial effect, but when given between immunization and manifestation of clinical symptoms, CIA could be prevented completely. Moreover, these monkeys became resistant to the disease, because no arthritic activity could be observed upon a booster immunization with type II collagen ( CII ). The suppression of disease by CsA is reflected in reduced antibody levels to CII .