Open AccessHuman colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down‐regulate proliferative responses of primed allogeneic peripheral blood mononuclear cells after rechallenge with antigens
Author(s) -
DALTON H. R.,
DIPAOLO M. C.,
SACHDEV G. K.,
CROTTY B.,
HOANG P.,
JEWELL D. P.
Publication year - 1993
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1993.tb06503.x
Subject(s) - peripheral blood mononuclear cell , phytohaemagglutinin , immunology , intraepithelial lymphocyte , inflammatory bowel disease , antigen , medicine , peripheral blood , disease , biology , immune system , pathology , in vitro , biochemistry
SUMMARY Human colonic intraepithelial lymphocytes from control subjects down‐regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens or phytohaemagglutinin (PHA). In contrast, human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down‐regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens. These findings may be important in the development and maintenance of the mucosal immunological activation of inflammatory bowel disease.