Open AccessModulation of α 1 ‐acid glycoprotein (AGP) gene induction following honey bee venom administration to adjuvant arthritic (AA) rats; possible role of AGP on AA development
Author(s) -
YIANGOU M.,
KONIDARIS C.,
VICTORATOS P.,
HADJIPHTROUKOUROUNAKIS L.
Publication year - 1993
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1993.tb05994.x
Subject(s) - immunology , arthritis , tumor necrosis factor alpha , adjuvant , acute phase protein , pharmacology , glycoprotein , medicine , biology , inflammation , microbiology and biotechnology
SUMMARY Honey bee venom (HBV) administration to adjuvant arthritic (AA) rats resulted in a significant suppression of arthritis and in suppression of the hepatic acute phase α 1 ‐acid glycoprotein (AGP) gene induction at the early stages of disease development. AGP administration in AA rats resulted in acceleration of arthritis development and in increase of severity and duration of the disease. lL‐1, IL‐6. tumour necrosis factor (TNF) and glucocorticoids alone are not responsible for thc HBV‐mediated AGP gene down‐regulation. These results indicate that AGP gene expression in AA and HBV‐treated AA rats involves the interaction of several factors, and that AGP plays a role for AA development in rats.