Open AccessHIV induces deletion of T cell receptor variable gene product‐specific T cells
Author(s) -
BANSAL A. S.,
GREEN L. M.,
KHOO S. H.,
PUMPHREY R. S. H.,
HAENEY M. R.,
MANDAL B. K.
Publication year - 1993
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1993.tb05970.x
Subject(s) - t cell receptor , cd8 , immunology , biology , beta (programming language) , t cell , t lymphocyte , virology , alpha (finance) , microbiology and biotechnology , antigen , medicine , immune system , construct validity , nursing , patient satisfaction , computer science , programming language
SUMMARY Using a flow cytometrie method, CD4 + , CD8 + , αβ TCR + and TCR variable region gene product (TVRGP)‐specific T cells were analysed in heallhy heterosexual males (HHeM). HIV‐seronegative homosexual males (SNHM). asymptomatic seropositive homosexual males (ASPH) and homosexual males with AIDS who were either well (AIDS‐A). or unwell in hospilal (AIDS‐B). Total CD4 + and CD8 + T cell numbers were similar in HHeM and SNHM. CD4 + T cells were significantly reduced in ASPH relative to both HHeM and SNHM and in AIDS‐A and AIDS‐B relative to SNHM. TVRGP‐specific T cells expressed as a percentage of TCR αβ + cells showed no significant difference in HHeM. SNHM and AIDS‐B. The proportion of αβ + cells expressing the Vβ5.1, Vβ12 and Vα2 gene product (GP) was. however, significantly reduced in ASPH and AIDS‐B relative to HHeM. SNHM and AIDS‐A. Possible causes of TVRGP‐specific T cell deletion arc discussed.