Open AccessComparative analysis of biological activities of Der p I ‐derived peptides on Fc receptor‐bearing cells from Dermatophagoides pteronyssinus‐sensitive patients
Author(s) -
JEANNIN P.,
PESTEL J.,
BOSSUS M.,
LASSALLE P.,
TARTAR A.,
TONNEL A.B.
Publication year - 1993
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1993.tb05959.x
Subject(s) - peptide , receptor , immunoglobulin e , immunology , pyroglyphidae , immune system , allergen , antibody , stimulation , chemistry , biology , house dust mite , microbiology and biotechnology , allergy , biochemistry , endocrinology
SUMMARY The ability of Tour uncoupled synthetic peptides (p52–71, p117–133, p176–187, p188–199) derived from Der p I , a major allergen from the house dust mite Dermatophagoides pteronyssinus (Dpt ) to stimulate FcεR + cells from Dpt ‐sensitive patients was comparatively analysed. Each free peptide may specifically stimulate basophils (FcεRI + cells) and platelets (FcεRII + cells) from patients with significant levels of anti ‐Der p I IgE antibodies; p52–71 and p 117–133 appear the best cell stimulation inducers. Both concentration‐dependent biological activities of Der p I ‐peptide on FcεR + cells are enhanced by coupling peptide to a carrier (as human serum albumin). Interestingly each Der p I sensitive patient tested presents an individual pattern of response to peptide. Thus, from our results it appears that different Der p I sequences could be involved in the immune response to Der p I .