Open AccessIL‐1β and IL‐3‐like activity in preterm infants
Author(s) -
BESSLER H.,
SIROTA L.,
NOTTI I.,
DULITZKY F.,
DJALDETTI M.
Publication year - 1993
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1993.tb05902.x
Subject(s) - immunology , medicine , biology
SUMMARY The capacity of peripheral blood mononuclear cells (PBMC) of pretert ntieonaies lo release I L‐ l /f and IL‐3‐like activity (IL‐3‐LA) has been investigaied. In the present study it was found that this capacity is significantly lower than that of their mothers and or eontrol adults. In addition, the results showed that preterm serum has a lower stitnulatory effect on IL‐1β production and an inhibitory effect on IL‐3‐LA secretion by PBMC of adult controls, in comparison with maternal and adull sera. These findings suggest an additional Teedback mechanism for control of hacmatopoiesis in premature neonates. It is possible that the lower production of IL‐1β and IL‐3‐VLA may be involved in the increased susceptibility to infections of preterm newboms.