Open AccessPrognostic value of serum immunoglobulin A antibodies to pol gene products during HIV‐1 infection
Author(s) -
QUESNEL A.,
POZZETTO B.,
MOJA P.,
GRATTARD F.,
LUCHT F. R.,
TOURAINE J. L.,
GAUDIN O. G.,
GENIN C.
Publication year - 1993
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1993.tb05889.x
Subject(s) - antibody , immunology , immunoglobulin a , biology , protein subunit , gene , immunoglobulin g , genetics
SUMMARY Serum specimens from 66 HIV‐t‐infected subjects were tested by ELISA for the presence of IgA antibodies to HIV‐t:44 samples were found positive and 37 were confirmed by immunoblot. In these subjects, the presence of anti‐HIV IgA antibodies was studied in relation to the total count of circulating CD4 + lymphocytes and to the level of serum IgA. A significative correlation ( P < 0·03) was found between the absence of IgA to the subunit p68 of the reverse transcriptase and a count of CD4 + cell < 400/mm 3 or total IgA level over 4–25 g/l . The same pattern was observed for the IgA antibodies to the p52 subunit but the association was just not significant ( P < 0·07). No significant decrease was noted for the IgA directed towards the other proteins of HIV‐1, especially the products of the gag gene.