Open AccessComparative antibody response to salmonella antigens in genetically resistant and susceptible mice
Author(s) -
XU H. R.,
TAN Y. Y.,
HSU H. S.,
MONCURE C. W.,
WANG X. M.
Publication year - 1993
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1993.tb03357.x
Subject(s) - salmonella , biology , antigen , microbiology and biotechnology , virulence , antibody , virology , inoculation , pathogen , antibody response , lipopolysaccharide , genetically modified organism , immunology , bacteria , gene , genetics
SUMMARY The ELISA was used to titrate the antibody response in mice inoculated with salmonella antigens. The genetically resistant A/J and susceptible C57BL/6J mice were either infected with the virulent or the avirulent Salmonella typhimurium . Alternatively, they were inoculated either once or twice with the heat‐killed salmonella vaccine. No appreciable difference could be detected in the relative ability of these two strains of mice to produce antibodies against the lipopolysaccharide antigens of this pathogen under these four conditions.