Open AccessDecreased polymorphonuclear leucocyte chemotactic response to leukotriene B 4 in cystic fibrosis
Author(s) -
LAWRENCE R. H.,
SORRELL T. C.
Publication year - 1992
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1111/j.1365-2249.1992.tb06953.x
Subject(s) - leukotriene b4 , chemotaxis , cystic fibrosis , immunology , pathogenesis , in vivo , medicine , leukotriene , fibrosis , granulocyte , inflammation , receptor , asthma , biology , microbiology and biotechnology
SUMMARY Evidence that leukotriene B 4 (LTB 4 ) is a significant inflammatory mediator in chronic pseudomonal respiratory disease was sought in adolescents and young adults with cystic fibrosis. Specific chemotaxis of peripheral blood polymorphonuclear leucocytes (PMN) was used as an indirect measure of remote in vivo exposure to LTB 4 . PMN from 17 patients showed a significant decrease in chemotaxis to 10 −7 ‐10 −9 m LTB 4 , but normal responses to 10 −8 m n ‐formyl‐methionyl‐leucyl‐phenylalanine and 4 mg/ml casein, when compared with 17 healthy age‐ and sex‐matched controls. This result is consistent with chronic production of LTB 4 , and specific deactivation of circulating PMN receptors for LTB 4 in patients with cystic fibrosis. Pharmacologic inhibition of LTB 4 production in vivo may help elucidate its role in the pathogenesis of lung damage in cystic fibrosis.